💉 Can TRT Help Lower Cholesterol?

The Surprising Cardiovascular Benefits of Testosterone Replacement Therapy

When you think ofIf you’ve been battling high LDL, low HDL, or elevated triglycerides — especially alongside symptoms of low testosterone — this might be the missing link in your health journey.

Testosterone Replacement Therapy (TRT), your mind might jump to muscle gains, increased energy, or better libido. But here’s something you may not know: TRT can significantly improve your cholesterol levels and support your long-term heart health.

🧪 What the Research Says About TRT and Cholesterol

✅ Total Cholesterol & LDL (Bad Cholesterol)

A 5-year study of over 1,000 hypogonadal men published in The Journal of Clinical Endocrinology & Metabolism found that:

• Total cholesterol dropped by 30.2 mg/dL

• LDL (bad cholesterol) decreased by 20.7 mg/dL

• Results were statistically significant (p < 0.0001) and sustained long term
  (Zitzmann et al., 2012)
  
  

Another meta-analysis in BMC Medicine analyzed over 30 randomized controlled trials and reported:

• LDL reduced by 6.23 mg/dL

• Total cholesterol lowered by 10.1 mg/dL on average
  (Corona et al., 2013)
  
  

📉 These numbers might seem small—but over time, even modest improvements in cholesterol can drastically reduce your risk of cardiovascular disease.

🔄 HDL (Good Cholesterol): What Happens?

Older testosterone formulations sometimes lowered HDL. But modern TRT protocols—using transdermal gels or carefully dosed injections—show a neutral or mildly positive effect:

• HDL increased by 1.1 to 2.3 mg/dL in several studies

• No significant negative changes reported with proper dosing
  (Traish, 2020)

🔻 Triglycerides: Another Big Win

In a 2011 study in Diabetes, Obesity and Metabolism, TRT led to:

• Triglyceride reduction of 24.9 mg/dL (from a ~186 mg/dL baseline)

• Major improvements in the Triglyceride-to-HDL ratio, a powerful heart health marker
  (Saad et al., 2011)
  
  

❤️ Cardiovascular Risk: TRT Is NOT the Villain

Some old studies warned TRT might increase heart attack risk. But larger, more recent studies show the opposite:

A 2015 study published in Mayo Clinic Proceedings (n = 8,700+) found that:

• Men on TRT had a 33% LOWER risk of heart attack compared to untreated men

• The best results were in those who achieved normalized testosterone levels
  (Sharma et al., 2015)
  
  

🧬 Why Does Testosterone Affect Cholesterol?

TRT helps balance your cholesterol and lipid markers through mechanisms like:

• ✅ Reduced visceral fat (belly fat)

• ✅ Improved insulin sensitivity

• ✅ Enhanced liver enzyme activity (hepatic lipase)

• ✅ Activation of androgen receptors that influence lipid metabolism
  
  

It’s a full-body domino effect: optimize testosterone → improve metabolism → lower inflammation and cholesterol.

📍 Local Help in Monmouth County, NJ

At Jersey Shore TRT, we combine evidence-based hormone therapy with lifestyle coaching, lab tracking, and nutrition support.

We treat the whole person—not just your testosterone level. If you're struggling with energy, weight, or cholesterol, we may be able to help you feel like yourself again.

🗓️ Book Your Free Consultation

Ready to explore how TRT might help your cholesterol and overall health?

📞 Call us or message us at (848)900-1180

💬 Email us at info@jerseyshoretrt.com

📍 Serving Monmouth County & the Jersey Shore

📚 References

1. Zitzmann M, et al. J Clin Endocrinol Metab. 2012;97(7):2670–2677.

2. Corona G, et al. BMC Med. 2013;11:108.

3. Traish AM. Curr Opin Endocrinol Diabetes Obes. 2020;27(3):169–179.

4. Saad F, et al. Diabetes Obes Metab. 2011;13(6):614–623.

5. Sharma R, et al. Mayo Clin Proc. 2015;90(6):732–740.